Effects of Strain and Age on Prophylaxis and Co-Carcinogenesis of Urethan- induced Mouse Lung Adenomas by Butylated Hydroxytoluene1

نویسندگان

  • Alvin M. Malkinson
  • Larry G. Thaete
چکیده

A single i.p. injection of butylated hydroxytoluene (BHT) 6 h before a single urethan injection had varying effects on lung tumorigenesis in mice of different strains and ages. Strains exhibiting both high (A/J, SWR/J) and low (BALB/cByJ, 129/J, CS7BL/6J) susceptibility to urethan tumorigenesis were tested in this study. BHT treatment decreased tumor multiplicity by an average of 32% in adult A/J mice but acted as a cocarcinogen by increasing tumor number 48% in adult SWR/J mice, 240% in adult C57BL/6J mice, 655% in adult 129/J mice, and 38% in 14-dayold A/J mice. The numbers of both alveolar type 2 cell-derived and bronchiolar Clara cell-derived lung adenomas were similarly affected by these BHT treatments. Such BHT pre-treatment had no effect on ade noma multiplicity in either young or adult BALB/cByJ mice. Multiplicity in young BALB/cByJ mice was also unaffected by chronic BHT admin istration following urethan, even though multiplicities increased severalfold with such treatment in adult mice of this strain. Since the mice showing co-carcinogenesis by BHT include strains which are both highly susceptible and relatively resistant to urethan induction of lung tumors, our results support a distinction between genes regulating susceptibility to urethan carcinogenesis and to tumor modulation by BHT.

برای دانلود رایگان متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Effects of strain and age on prophylaxis and co-carcinogenesis of urethan-induced mouse lung adenomas by butylated hydroxytoluene.

A single i.p. injection of butylated hydroxytoluene (BHT) 6 h before a single urethan injection had varying effects on lung tumorigenesis in mice of different strains and ages. Strains exhibiting both high (A/J, SWR/J) and low (BALB/cByJ, 129/J, C57BL/6J) susceptibility to urethan tumorigenesis were tested in this study. BHT treatment decreased tumor multiplicity by an average of 32% in adult A...

متن کامل

Promotion of lung tumors in mice.

Several elements of two-stage carcinogenesis apply to the development of lung tumors in Strain A or Swiss-Webster mice. At least three agents which have been identified as promoters in skin, urinary bladder and liver will also enhance tumor formation in lung; phorbol, saccharin and butylated hydroxytoluene (BHT). The antioxidant BHT acts in many respects like a typical promoting agent: it is ef...

متن کامل

The predictive value of skin allograft survival times during the development of urethan-induced lung adenomas in BALB-c mice.

The possibility that depression of cell-mediated immu nity facilitates the carcinogenic effect of urethan on the mouse lung was studied in the BALB/c strain which is highly susceptible to lung tumor development. Lung adenomas were induced by giving 4-day-old mice an i.p. injection of 1.0 mg urethan. Two months after injection, urethan-treated and 0.85% NaCl solution-treated control mice were te...

متن کامل

The Predictive Value of Skin Allograft Survival Times during the Development of U retnan-induced Lung Adenomas in BALB/c Mice1

The possibility that depression of cell-mediated immu nity facilitates the carcinogenic effect of urethan on the mouse lung was studied in the BALB/c strain which is highly susceptible to lung tumor development. Lung adenomas were induced by giving 4-day-old mice an i.p. injection of 1.0 mg urethan. Two months after injection, urethan-treated and 0.85% NaCl solution-treated control mice were te...

متن کامل

Decrease in the protein kinase C-catalyzed phosphorylation of an endogenous lung protein (Mr 36,000) following treatment of mice with the tumor-modulatory agent butylated hydroxytoluene.

Butylated hydroxytoluene (BHT) causes transient lung damage in mice, and it can either inhibit or enhance carcinogen induction of tumors in internal organs, such as urethan-induced lung adenomas. Since protein kinase C (Pk-C) may mediate the action of one class of tumor-modulatory agents, the phorbol esters which promote skin tumorigenesis, we are examining the hypothesis that Pk-C is involved ...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

عنوان ژورنال:

دوره   شماره 

صفحات  -

تاریخ انتشار 2006